,Conventional cardiovascular risk markers,,,,,,,,,,,,EV numbers and sizes,,,,,,,EV thrombogenic potential,,,,,,,,,,,Thrombogenic markers,,,,,,,,,,,,,,,,
,,,,,,,,,,,,,Total EV numbers_NTA (per ml blood),EV sizes_NTA (nm),,EV subpopulation numbers_FCM (per ml blood),,,,Purified EVs in VFP ,,,,,VFP alone,,,,,,Platelet aggregation,,,,,Thrombin generation,,,,,Thrombodynamics,,,,,,
Subjects,Gender,Age (years),BMI((kg/m^2),SBP (mmHg),DBP (mmHg),TC (mmol/L),TAG (mmol/L),HDL (mmol/L),TC/HDL,Glucose (mmol/L),Risk (%),,TEVs,Mean sizes,Mode sizes,PS+EVs,PDEVs,EDEVs,,Lag time for thrombin generation (min),Peak thrombin concentration (nM),Time to peak thrombin concentration(min),Velocity index,ETP (nM thrombin x min),Lag time for thrombin generation (min),Peak thrombin concentration (nM),Time to peak thrombin concentration(min),Velocity index,ETP (nM thrombin x min),,ADP_EC50,CRP_E50,EPI_E50,TRAP-6_E50,U4_E50,Lag time for thrombin generation (min),Peak thrombin concentration (nM),Time to peak thrombin concentration(min),Velocity index,ETP (nM thrombin x min),Rate of clot growth (um/min),Lag time (min),Initial rate of clot growth (um/min),Clot size at 30 min (um),Clot density,Lysis onset time,Lysis progression
HF01,male,65,19.9,137,71,3.96,0.82,1.33,3,5.58,12.50%,,2.23E+10,91,64,1.38E+07,2.08E+07,9.90E+05,,21.5,70.47,37,5.18,1790.61,27.5,20.09,42,1.39,336.76,,1.65E-04,1.11E-05,1.41E-05,1.95E-04,3.57E-03,31,50.21,52,2.4,772.2,33.4,0.7,62.9,1355,14472,18.7,23
HF02,male,65,24.6,117,67,6.37,0.85,1.57,4.1,5.27,14.10%,,2.40E+10,117,80,3.33E+07,2.49E+07,7.27E+05,,,,,,,26,29.44,48.5,1.34,489.2,,4.82E-04,4.00E-03,1.03E+00,8.27E-06,1.59E-11,27,53.41,53,2.1,1121.39,27.5,0.9,57.5,1147,20580,30.4,14.9
HF04,male,62,24.5,140,84,5.63,0.62,1.63,3.5,8.25,10.80%,,1.74E+10,85,61,3.77E+07,2.50E+07,7.84E+05,,20.5,103.28,32,9.09,2720.12,27.5,20.09,42,1.39,336.76,,7.52E-06,4.90E-08,7.24E-06,5.09E-04,1.93E-04,28,59.93,45,3.7,1203.88,30.7,0.8,59.2,1270,20442,31.9,16.4
HF05,female,68,29.3,153,77,5.93,1.45,1.24,4.8,5.92,17.10%,,3.73E+10,95,63,3.78E+07,1.14E+07,8.66E+05,,21.5,61.46,39,3.98,1469.66,26,29.44,48.5,1.34,489.2,,2.82E-03,6.61E-05,2.36E-04,8.45E-04,5.14E-04,26,62.84,53,2.3,1258.51,29.3,0.8,60.1,1217,25840,24.8,14.5
HF06,male,54,27.3,129,76,5.82,0.81,1.55,3.8,5.68,12.60%,,5.51E+10,115,86,1.68E+07,7.50E+06,8.83E+05,,21.5,68.43,37,4.47,1465.7,32,32.9,58,1.27,350.67,,1.59E-03,3.57E-05,1.05E-03,1.41E-03,1.84E-04,28.5,70.57,48.5,3.8,1449.62,32.2,0.8,58.6,1287,18015,27.2,12.4
HF07,male,58,30.0,142,92,6.25,1.99,1.36,4.6,5.3,10.20%,,5.00E+10,80,63,1.18E+07,1.14E+07,4.82E+05,,18,115.04,29.5,10.03,2627.51,23,33.3,42.5,1.71,708.09,,1.21E-03,2.35E-05,1.20E-04,1.13E-03,3.23E-04,27,51.94,51,2.2,991.5,30.5,1,56.1,1206,19258,31.9,13.3
HF08,female,67,28.3,113,72,5.91,1.29,1.68,3.5,5.71,10.30%,,3.45E+10,80,65,5.27E+07,2.77E+07,1.03E+06,,17,131.64,26,14.88,3040.77,0,0,0,0,0,,8.38E-04,3.25E-05,6.36E-05,8.69E-04,1.74E-04,19,150.11,30,13.7,3767.66,33.2,0.9,64.3,1354,24638,42.4,14.2
HF09,female,67,26.9,127,75,6.18,1.36,1.64,3.8,5.51,10.50%,,2.07E+10,90,63,2.80E+07,1.76E+07,8.67E+05,,13,158.07,23.5,15.22,3110.74,13.5,109.99,24.5,10.12,2011.02,,5.82E-03,3.88E-05,7.81E-05,2.54E-03,1.96E-03,31,46.32,57.5,1.7,595.68,30.2,1,59.8,1280,24548,27.6,17.1
HF10,female,68,24.8,129,71,6.25,0.76,1.95,3.2,5.28,10.50%,,2.28E+10,93,71,3.35E+07,1.92E+07,4.52E+05,,21.5,40.56,38,2.65,959.71,30,6.37,54.5,0.26,38.8,,1.62E-03,1.44E-05,3.90E-05,1.33E-03,5.42E-04,30,59.65,57,2.2,1059.98,30.3,0.8,58.4,1249,21229,45.7,9.7
HF11,female,66,25.4,134,80,5.52,1.85,1.35,4.1,5.35,10.40%,,6.65E+10,79,65,2.62E+07,1.76E+07,8.99E+05,,14.5,79.54,27,6.38,2002.88,30,6.37,54.5,0.26,38.8,,3.77E-03,3.53E-05,1.28E-04,1.07E-03,1.03E-03,23.5,102.61,42,5.6,2442.62,32.7,0.9,61.7,1328,19684,33.6,18.7
HF12,female,70,25.0,120,65,6.49,0.84,1.44,4.5,5.51,14.40%,,3.00E+10,91,77,1.57E+07,1.76E+07,6.01E+05,,22,78.64,41,4.24,1820.24,27.5,34.11,49.5,1.69,548.93,,6.43E-04,5.35E-05,2.58E-04,4.30E-04,1.16E-03,31,70.74,50,3.7,1334.89,32.7,1,57.2,1279,24321,24.6,15.3
HF13,male,63,22.6,125,77,5.71,1.3,1.68,3.4,5.99,10.30%,,3.08E+10,102,84,3.65E+07,2.05E+07,5.89E+05,,22.5,77.03,44,3.58,1660.35,27.5,34.11,49.5,1.69,548.93,,5.63E-04,1.70E-04,6.48E-05,1.99E-04,1.07E-03,25.5,97.86,45.5,4.9,2234.08,34.6,0.9,67.5,1424,18962,22.6,20
HF14,male,62,21.7,177,89,7.94,1.67,1.7,4.7,6.3,17.70%,,7.84E+10,93,76,4.23E+07,3.04E+07,1.96E+06,,22,72.55,33.5,6.3,1759.14,33.5,5.66,47,0.41,45.42,,1.14E-03,3.58E-05,2.71E-04,3.42E-04,2.34E-03,33,47.12,57,2,785.13,31.5,0.8,60.4,1277,20560,35.9,15.2
HF15,female,70,24.8,151,91,5.11,0.84,1.69,3,4.97,12.70%,,3.64E+10,110,78,2.49E+07,2.17E+07,2.14E+06,,17,61.84,28,5.62,1113.39,16,48.73,26.5,4.66,654.81,,6.70E-04,1.94E-05,2.26E-04,2.06E-04,3.91E-04,26,67.87,44,3.8,1517.94,33.7,0.8,58.4,1360,19224,22.1,23.5
HF16,male,65,28.2,137,84,6.37,2.56,1.92,3.3,6.05,18.00%,,1.52E+11,101,80,3.08E+07,1.69E+07,2.24E+06,,30.5,17.98,42,1.56,229.64,0,0,0,0,0,,5.98E-04,1.34E-05,1.60E-04,2.83E-03,1.18E-04,19.5,141.75,36,8.7,3441.8,33.3,0.9,62.6,1309,18715,13.7,22.3
HF17,male,67,22.9,112,76,7.94,1.67,1.7,4.7,6.3,18.50%,,3.84E+10,108,91,2.61E+07,1.82E+07,1.24E+06,,25,27.43,50,1.09,546.68,34.5,9.49,53,0.5,114.06,,1.34E-05,2.84E-06,9.93E-06,3.52E-03,1.57E-12,29,63.55,50,3,1116.36,32.2,1,58.1,1291,23824,21.3,20.4
HF18,male,57,26.6,115,74,6.14,2.49,1.51,4.1,5.79,10.90%,,2.77E+10,94,74,7.08E+07,3.64E+07,2.49E+06,,22.5,31.88,41,1.73,684.53,34.5,9.49,53,0.5,114.06,,7.05E-04,2.36E-05,1.15E-04,3.08E-03,2.25E-04,27,64.56,57,2.2,1047,32.9,1.1,59.3,1323,21405,22.4,14.2
HF19,male,62,24.9,120,80,5.96,1.16,1.38,4.3,5.64,11.70%,,3.65E+10,98,76,4.95E+07,3.54E+07,1.14E+06,,13.5,148.79,25,12.97,3153.39,13.5,109.99,24.5,10.12,2011.02,,2.30E-03,2.22E-05,8.07E-04,5.84E-03,1.87E-04,29,70.32,50,3.4,1316.69,35.6,0.8,58.3,1339,21266,20.4,20.5
HF20,male,70,25.7,142,77,3.94,0.65,1.44,2.7,5.34,17.10%,,4.65E+10,113,90,1.45E+07,1.09E+07,1.99E+06,,18,63.07,30.5,5.08,1159.53,16,48.73,26.5,4.66,654.81,,1.33E-03,2.30E-05,9.06E-04,7.12E-03,3.50E-04,25,115.51,50,4.6,2474.08,34.9,0.8,60.4,1371,23723,28,18.2
HF21,male,66,27.3,121,75,5.86,2.2,1.19,4.9,5.35,17.10%,,7.75E+10,87,69,2.72E+07,1.93E+07,8.02E+05,,13.5,138.91,25,12.11,2746.75,13.5,109.99,24.5,10.12,2011.02,,5.22E-04,1.08E-05,3.10E-04,3.53E-03,8.60E-05,27,102.56,50,4.5,2257.78,33.9,1.2,64.3,1375,20455,44.1,12.9
HF22,male,55,27.8,134,86,5.94,1.66,1.11,5.4,6.53,10.10%,,5.62E+10,84,68,2.62E+07,2.15E+07,1.90E+06,,24,62.69,41.5,3.66,1392.42,33.5,5.66,47,0.41,45.42,,2.11E-03,1.43E-05,4.45E-04,6.16E-03,3.52E-04,25,93.13,40,6.4,2131.86,39.5,0.9,62.9,1479,22013,34.1,12.4
HF23,male,62,22.1,129,76,5.71,0.58,2.53,2.3,6.27,10.00%,,1.96E+10,92,68,1.52E+07,2.16E+07,1.91E+06,,19,78.1,33,7.63,1715.62,34.5,2.65,52,0.16,4.45,,7.66E-04,1.49E-05,1.22E-04,5.23E-03,4.38E-04,33,34.64,50,2,456.22,30.2,1,60.2,1201,19875,26.6,14.2
HF24,female,67,20.5,115,60,6.89,0.65,1.58,4.4,5.26,10.70%,,1.06E+10,125,93,3.63E+07,2.91E+07,1.53E+06,,25,50.31,42.5,2.98,1192.76,34.5,2.65,52,0.16,4.45,,3.34E-03,6.78E-05,9.56E-04,2.74E-03,1.38E-04,23,88.48,44,4.2,2080.16,30.2,0.9,57.6,1235,25637,33.4,12.9
HF25,male,66,24.7,141,82,4.25,0.36,1.6,2.7,6.15,12.60%,,3.07E+10,105,76,3.68E+07,2.47E+07,2.42E+06,,14,77.28,24,8.87,1456.46,18,4.88,28,0.49,9.89,,1.28E-03,1.40E-05,2.02E-04,7.42E-03,4.24E-04,25,65.89,51,2.5,1356.46,31.6,1,64.8,1278,21649,20,21.1
HF26,female,66,21.2,128,73,7.28,0.71,1.62,4.5,5.03,10.10%,,1.00E+10,103,67,3.90E+07,2.41E+07,7.69E+05,,16.5,89.41,28,7.82,1801.13,22,29.37,38,1.85,481.85,,3.57E-03,2.69E-05,9.74E-05,9.96E-03,9.04E-04,34,49.69,57,2.2,800.55,30,1,58,1232,20107,25.2,16.3
HF27,male,67,22.6,136,84,6.42,1.31,1.38,4.6,5.26,16.80%,,3.74E+10,104,73,5.33E+07,3.92E+07,2.05E+06,,21.5,75.68,36.5,5.68,1788.95,32,32.9,58,1.27,350.67,,2.13E-03,1.75E-05,5.39E-04,4.36E-03,1.43E-04,27.5,80.29,47,4.2,1619.05,33.4,1,59.6,1500,30665,27.1,17.7
HF28,female,67,21.9,116,63,7.8,0.88,1.38,5.6,5.37,10.60%,,1.75E+10,100,75,2.60E+07,2.60E+07,1.12E+06,,22,65.51,37.5,4.22,1573.89,33,26.22,48,1.75,297.02,,4.22E-04,7.95E-06,3.31E-05,9.97E-04,4.13E-08,28,67.45,54.5,2.6,1237.85,31.9,0.9,59.3,1314,22285,24.8,16.9
HF29,male,62,25.9,127,74,5,1.17,1.37,3.7,6.93,10.50%,,3.55E+10,98,70,4.83E+07,2.19E+07,7.12E+05,,24.5,51.94,44,2.66,1180.59,33,26.22,48,1.75,297.02,,1.19E-03,6.14E-06,1.14E-04,9.16E-03,4.22E-04,28,52.66,54.5,2,979.56,30.3,1,59,1260,18028,23.6,17.1
HF30,male,68,27.6,130,81,5.25,2.11,1.05,5,6.37,19.70%,,1.27E+11,89,70,3.18E+07,1.32E+07,1.69E+06,,24.5,40.81,42.5,2.27,814.07,29,14.01,52,0.61,157.81,,8.47E-03,3.47E-05,3.21E-05,1.30E-02,6.24E-04,26.5,125.48,44.5,7,2808.06,34.1,0.9,61.8,1660,22426,28.3,14.1
HF31,female,64,24.5,152,94,6.67,0.64,1.64,4.1,4.93,10.60%,,3.67E+10,98,66,3.45E+07,1.35E+07,1.17E+06,,20,78.27,41,4.32,1932.95,29,14.01,52,0.61,157.81,,3.16E-04,9.71E-06,2.40E-04,5.82E-03,9.48E-05,28,94.74,45,5.6,2132.77,30,1,56.2,1211,28169,22.6,15.2
HF32,female,63,23.9,139,78,6.53,1.08,2.02,3.2,6,10.00%,,3.79E+10,89,70,3.69E+07,2.46E+07,2.53E+06,,16.5,151.91,27.5,14.31,3248.27,13.5,109.99,24.5,10.12,2011.02,,8.07E-04,1.20E-05,1.45E-04,7.34E-03,2.85E-04,27,45.09,50,2,820.01,32.3,1.1,59.8,1274,20200,21.5,17.6
HF33,female,62,26.2,129,74,7.69,1.02,1.87,4.1,5.49,10.00%,,3.43E+10,118,77,4.49E+07,2.55E+07,1.99E+05,,14,156.68,24,15.77,3329.77,13.5,109.99,24.5,10.12,2011.02,,1.09E-03,1.53E-05,3.10E-04,1.09E-02,1.04E-04,31,64.66,54,2.9,1164.35,30.7,1,56.5,1223,25857,42.1,7.3
HF34,male,68,29.6,156,92,6.26,0.99,1.38,4.5,6.32,20.00%,,5.67E+10,98,72,7.67E+07,3.95E+07,1.22E+06,,24,51.54,45,2.45,1112.99,38,5.51,57,0.29,12.69,,2.99E-04,7.83E-06,4.39E-04,3.04E-03,8.20E-05,31,64.86,50,3.4,1151.08,31.8,0.8,58.4,1278,17824,32.8,13.3
HF35,male,63,33.4,150,91,6.32,2.56,1.48,4.3,6.76,19.60%,,4.08E+11,102,79,6.08E+07,2.83E+07,1.06E+06,,22.5,36.68,51,1.37,711.57,38,5.51,57,0.29,12.69,,1.50E-03,3.52E-05,1.76E-04,6.95E-03,4.71E-04,23.5,177.79,37.5,12.8,4011.77,39.3,1,61.2,1438,26121,27.5,19.9
HF36,female,62,27.3,154,104,7.9,1.93,1.99,4,5.47,10.00%,,5.68E+10,91,74,4.30E+07,2.30E+07,1.54E+06,,22.5,37.16,35.5,3.23,572.04,26,12.62,51,0.5,76.47,,1.93E-03,9.64E-06,1.08E-04,7.63E-03,9.61E-05,23.5,124.14,39.5,7.8,2944.47,34.8,1.1,58.3,1330,21277,26.9,17.9
HF37,female,66,21.0,125,77,4.85,1.22,1.55,3.1,5.26,10.50%,,6.83E+10,114,82,3.15E+07,1.59E+07,1.54E+06,,24.5,30.12,51,1.14,414.01,26,12.62,51,0.5,76.47,,1.19E-03,3.28E-05,2.51E-05,8.51E-03,1.01E-04,22,82.83,36,5.9,1852.49,34,1,60,1302,21254,30,16.5
HF38,male,65,25.1,142,72,6.09,0.85,1.74,3.5,5.95,13.90%,,1.84E+10,113,79,4.64E+07,2.01E+07,1.93E+06,,29,40.78,49.5,1.99,566.3,32,12.55,54.5,0.55,145.14,,8.69E-04,1.74E-05,7.25E-04,8.30E-03,2.52E-04,29,68.2,50,3.3,1238.72,32.3,1.2,56.2,1246,22600,30.8,20.1
HF39,female,65,25.4,140,88,5.51,1.82,1.69,3.3,5.39,10.30%,,3.63E+10,88,68,3.24E+07,1.90E+07,6.76E+05,,27.5,31.59,49.5,1.44,437.49,32,12.55,54.5,0.55,145.14,,1.36E-03,1.87E-05,4.10E-05,4.46E-03,1.32E-04,21.5,84.13,39,4.8,1918.56,34.9,0.9,63.6,1383,22480,30,21.8
HF40,male,61,28.9,149,80,4.55,1.45,1.59,2.9,6.01,10.70%,,3.05E+10,86,69,2.56E+07,9.88E+06,8.26E+05,,27.5,38.32,42,3.28,678.6,33.5,0.73,48,0.06,0.36,,4.43E-03,2.19E-05,1.67E-04,6.09E-03,9.97E-04,26,72.18,49.5,3.1,1367.01,32.5,1.1,60.9,1317,28730,35.9,16.4
HF41,male,68,24.2,126,70,5.48,0.68,1.7,3.2,5.17,13.70%,,1.82E+10,100,75,2.50E+07,1.01E+07,6.12E+05,,20.5,80.78,34,5.84,1699.23,33.5,0.73,48,0.06,0.36,,4.69E-04,1.68E-05,1.11E-08,2.73E-03,1.96E-04,26,81.54,47,3.9,1627.48,32.5,0.9,62.3,1306,21531,28.5,15.3