The dataset consists of second language (English) learning data, collected from 132 Chinese learners aged 13 to 14 in two schools in China over a period of approximately 6 months. Learners were divided into four experimental groups with different technology-enhanced learning conditions (video enhancement, video enhancement plus self-regulation mechanism, digital flashcards, and digital flashcards plus self-regulation mechanism) and one control group with no intervention. The data was collected at three time points. At Time 1, quantitative data were collected through a pre-existing vocabulary knowledge test, a target vocabulary pre-test (measuring written form recognition, aural form recognition and meaning recall), and a self-regulation questionnaire. At Time 2, at the end of each learning intervention (a 5-week intervention, one session per week), quantitative data were collected through an immediate post-test of the target words. At time 3, quantitative data were collected one month after the last intervention session through a delayed post-test regarding the influence of repetitions under different technology-enhanced learning conditions.