This dataset contains behavioural data collected to investigate the anti‑nociceptive effects of psilocybin in a preclinical model of neuropathic pain in mice. The data were generated as part of research examining whether psilocybin can modulate sensory and pain‑related behaviours following nerve injury. The dataset includes results from a series of established behavioural assays designed to quantify different sensory modalities and motor function.

Specifically, static mechanical sensitivity was assessed using the von Frey test, dynamic mechanical sensitivity was measured using the brush test, and cold sensitivity was evaluated using a thermal preference place test. In addition, locomotor performance and general motor coordination were examined using the rotarod test. Together, these datasets provide a comprehensive behavioural profile relevant to sensory processing, nociception, and motor function in the context of psilocybin administration.