This dataset consists of twice-daily observations of barometric pressure from Durham Observatory (54.768 °N, 1.584 °W, barometer cistern 107.3 m above mean sea level, MSL) from 23 July 1843 to 31 December 1960. The Durham record, which is 98.7% complete, is by far the longest digital barometric pressure series in northern England, and fills a very large temporal and spatial gap in the International Surface Pressure Database (ISPD). A paper describing the data series has been accepted by Geoscience Data Journal, with publication expected in October 2021 (also available in CENTAUR). BOOK CHAPTER Substantially the same information will appear as Appendix 5 in Durham Weather and Climate since 1841, by Tim Burt and Stephen Burt, to be published by Oxford University Press in Spring 2022. If you use the data, please include a citation as follows: Burt, T and Burt, S (2021) A twice-daily barometric pressure record from Durham Observatory in north-east England, 1843-1960 v1.1. In Durham Weather and Climate since 1841. Oxford University Press, Appendix 5.