Human intervention trial data assessing the impact of cellobiose, oligofructose P95 and maltodextrin supplementation on the gut microbiome and metabolite profile

How to cite this Dataset

Huang, Manxi (2025): Human intervention trial data assessing the impact of cellobiose, oligofructose P95 and maltodextrin supplementation on the gut microbiome and metabolite profile. University of Reading. Dataset. https://researchdata.reading.ac.uk/id/eprint/1477

Description

This dataset contains the underlying experimental data for a human intervention trial investigating the effects of commercial cellobiose, oligofructose P95, and maltodextrin (placebo) on the gut microbiome community, metabolite changes, and gastrointestinal habits.

The data supports the findings reported in the manuscript: 'Exploring the prebiotic potential of commercial cellobiose: In vivo approach of commercial cellobiose compared to placebo (maltodextrin) and fructooligosaccharides: a randomized, controlled trial'.

This study is also presented as Chapter 5 of the PhD thesis: 'Extraction of cellobiose from spent coffee grounds and prebiotic potential of commercial cellobiose'.

Outcomes include:

- Gut microbiome profiling using Quantitative Microbiome Profiling (QMP) (Flow-FISH + 16S rRNA sequencing).
- Metabolite changes (Short-Chain Fatty Acids via GC-FID).
- Gastrointestinal tolerability and bowel habits.

Resource Type:

Dataset

Creators:

Huang, Manxi

Contributors:

Rastall, Bob

and Jackson, Peter

Rights-holders:

Manxi Huang

Data Publisher:

University of Reading

Publication Year:

2025

Data last accessed:

6 December 2025

DOI:

https://doi.org/10.17864/1947.001477

Metadata Record URL:

https://researchdata.reading.ac.uk/id/eprint/1477

Organisational units:

Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Food Microbial Sciences Research Group

Participating Organisations:

University of Reading

Keywords:

cellobiose, human intervention trial, gut microbiome, short-chain fatty acids (SCFA), prebiotic, 16S rRNA sequencing, quantitative microbiome profiling (QMP)

Rights: